Publications

Discover our work.

Explore publications from the Fang Laboratory spanning cell engineering, immune modulation, and biomaterial-enabled therapeutic systems.

● The Fang LaboratoryZhejiang University · Hangzhou

In press

167

Cyclic di-(3',5')-guanosine monophosphate loaded metal organic frameworks for mucosal immunization against giardiasis

Krishnan, N.; Miyamoto, Y.; Zhou, J.; Nieskens, N.; Zhang, J.; Fang, R.H.; Zhang, L.; Eckmann, L.

Infection and ImmunityIn press

166

Microproteomics of CA-MRSA uncovers bioactive endogenous peptides and virulent small open reading frames

Raygoza, J.; Wozniak, J.; Tan, M.; Van, S.; Castaneda, J.; Wierzbicki, I.; Sauceda, C.; McGrosso, D.; Aguilar, J.; Dores, M.; Schilcher, K.; Wei, X.; Fang, R.H.; Trejo, J.; Corriden, R.; Zhang, L.; Horswill, A.; Gonzalez, D.

Infection and ImmunityIn press

2026

165

A modular antigen anchoring strategy for cellular nanoparticle vaccines against Burkholderia pseudomallei

Krishnan, N.; Mohapatra, A.; Lam, E.; Wilkinson, E.; Urbano-Muñoz, F.; Hoenig, J.J.; Lee, J.; Nizet, O.; Lee, A.Y.; Fang, R.H.; Gao, W.; McMahon, B.; Kubicek-Sutherland, J.; Burtnick, M.; Brett, P.; Zhang, L.

ACS Nano2026Vol. 2022919-22930

164

Microrobots for pulmonary drug delivery

Li, Z.; Luan, H.; Fang, Z.; Ding, S.; Kobrin, R.; Fang, R.H.; Zhang, L.; Wang, J.

Nature Reviews Bioengineering2026Vol. 4319-335

163

Macrophage membrane-camouflaged nanoparticles as emerging therapeutics in metabolic dysfunction-associated steatotic liver disease

Ariyathanapong, N.; Ploypradith, K.; Yoshimura, P.; Thedrattanawong, C.; Wuestefeld, T.; Leelahavanichkul, A.; Jin, T.; Mao, L.; Fang, R.H.; Lee, Y.; Thamphiwatana, S.

Smart Materials in Medicine2026Vol. 777-92

162

Intratumoral manipulation of the immune microenvironment of solid tumors

Mao, L.; Xu, K.; Jin, T.; Yan, W.; Fang, R.H.

ACS Nano Medicine2026Vol. 1223-249

161

Nanomedicine for oral delivery: Strategies to overcome the biological barriers

Kubiatowicz, L.; Pourafzal, N.; Zhu, A.; Guo, Z.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Small Methods2026Vol. 102500624

2025

160

Bacterial membrane coating potentiates lipid nanoparticles for mRNA delivery

Wang, R.; Bao, L.; Yu, Y.; Zhang, R.; Guo, Z.; Kubiatowicz, L.; Krishnan, N.; Noh, I.; Wang, E.; Fang, R.H.; Gao, W.; Zhang, L.

Nano Letters2025Vol. 2517074-17081

159

Neuronal membrane-functionalized biohybrid microrobots for active decontamination of neurotoxins in aqueous environments

Li, Z.; Luan, H.; Fang, Z.; Shen, W.; Yu, Y.; Ji, J.; Kobrin, R.; Zhang, J.; Neuschul, S.; Tse, W.; Ding, S.; Wang, D.; Fang, R.H.; Gao, W.; Zhang, L.; Wang, J.

ACS Nano2025Vol. 1934123-34135

158

STING-adjuvanted outer membrane vesicle nanoparticle vaccine against Pseudomonas aeruginosa

Bjanes, E.; Krishnan, N.; Koh, T.; Ngo, A.; Cole, J.; Olson, J.; Cornax, I.; Chen, C.; Chavarria, N.; Dahesh, S.; Hannah, S.; Stream, A.; Zhang, J.; Besancon, H.; Sun, D.; Yendluri, S.; Morrill, S.; Zhou, J.; Mohapatra, A.; Fang, R.H.; Nizet, V.

JCI Insight2025Vol. 10e188105

157

Enzymatic cellular nanoparticles deliver payloads across mucosal barriers

Kubiatowicz, L.; Pourafzal, N.; Krishnan, N.; Bao, L.; Mohapatra, A.; Gao, W.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Bioconjugate Chemistry2025Vol. 361767-1774

156

Picoeukaryote-based biohybrid microrobots for active delivery in the kidney

Li, Z.; Wang, D.; Luan, H.; Chang, A.; Fang, Z.; Sun, L.; Ji, J.; Shen, W.; Yu, Y.; Yan, Y.; Ding, S.; Zhang, J.; Zhang, Y.; Peng, Y.; Fang, R.H.; Gao, W.; Zhang, L.; Wang, J.

Science Advances2025Vol. 11eadw8578

155

Macrophage-mimicking nanodiscs for treating systemic infection caused by methicillin-resistant Staphylococcus aureus

Feng, K.; Sun, L.; Zhou, Z.; Zhang, J.; Fang, R.H.; Gao, W.; Zhang, L.

Science Advances2025Vol. 11eadw7511

154

Hepatic endoplasmic reticulum-derived nanodiscs for broad-spectrum drug detoxification

Sun, L.; Feng, K.; Bai, D.; Yu, Y.; Shen, W.; Zhang, J.; Fang, R.H.; Gao, W.; Zhang, L.

Biomaterials2025Vol. 318123188

153

Nanoparticle approaches for manipulating cytokine delivery and neutralization

Wang, R.; Kubiatowicz, L.; Zhang, R.; Bao, L.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Frontiers in Immunology2025Vol. 161592795

152

Universal prophylactic antitumor vaccination using stem cell membrane-coated nanoparticles

Krishnan, N.; Zhou, J.; Mohapatra, A.; Ventura, C.; Duan, Y.; Lee, J.; Hoenig, J.; Nizet, O.; Gao, W.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Advanced Materials2025Vol. 372501616

151

Modular functionalization of cellular nanodiscs enables targeted delivery of chemotherapeutics into tumors

Noh, I.; Guo, Z.; Wang, R.; Zhu, A.; Krishnan, N.; Mohapatra, A.; Gao, W.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Journal of Controlled Release2025Vol. 378145-152

150

Aptamer-encapsulated cellular nanoparticles for neurotoxin neutralization

Kai, M.; Shen, W.; Wang, D.; Yu, Y.; Zhang, J.; Sun, L.; Fang, R.H.; Gao, W.; Zhang, L.

Advanced Healthcare Materials2025Vol. 142403539

149

Inhalable biohybrid microrobots: A non-invasive approach for lung treatment

Li, Z.; Guo, Z.; Zhang, F.; Sun, L.; Luan, H.; Fang, Z.; Dedrick, J.; Zhang, Y.; Tang, C.; Zhu, A.; Yu, Y.; Ding, S.; Wang, D.; Chang, A.; Yin, L.; Russell, L.; Gao, W.; Fang, R.H.; Zhang, L.; Wang, J.

Nature Communications2025Vol. 16666

2024

148

Cellular nanoparticles treat coronavirus infection in vivo

Yu, Y.; Silva-Ayala, D.; Zhou, Z.; Peng, Y.; Fang, R.H.; Gao, W.; Griffiths, A.; Zhang, L.

Nano Letters2024Vol. 2415136-15141

147

Towards multifunctional robotic pills

Mundaca-Uribe, R.*; Askarinam, N.*; Fang, R.H.*; Zhang, L.; Wang, J. (*Co-first author)

Nature Biomedical Engineering2024Vol. 81334-1346

146

Viral and nonviral nanocarriers for in vivo CRISPR-based gene editing

Guo, Z.; Zhu, A.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Nano Research2024Vol. 178904-8925

145

Neuronal membrane-derived nanodiscs for broad-spectrum neurotoxin detoxification

Wang, D.; Sun, L.; Shen, W.; Haggard, A.; Yu, Y.; Zhang, J.; Fang, R.H.; Gao, W.; Zhang, L.

ACS Nano2024Vol. 1825069-25080

144

Macrophage-mimicking cellular nanoparticles scavenge proinflammatory cytokines in specimens of patients with inflammatory disorders

Zhou, Z.; Mukundan, N.; Zhang, J.; Wu, Y.; Zhang, Q.; Wang, D.; Fang, R.H.; Gao, W.; Zhang, L.

Advanced Science2024Vol. 112401423

143

A genetically engineered neuronal membrane-based nanotoxoid elicits protective immunity against neurotoxins

Guo, Z.; Zhu, A.; Wei, X.; Jiang, Y.; Yu, Y.; Noh, I.; Gao, W.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Bioactive Materials2024Vol. 38321-330

142

Biohybrid microrobots regulate colonic cytokines and the epithelium barrier in inflammatory bowel disease

Li, Z.; Duan, Y.; Zhang, F.; Luan, H.; Shen, W.; Yu, Y.; Xian, N.; Guo, Z.; Zhang, E.; Yin, L.; Fang, R.H.; Gao, W.; Zhang, L.; Wang, J.

Science Robotics2024Vol. 9eadl2007

141

Rapid functionalisation of cell membrane-coated nanoparticles using a modular approach

Krishnan, N.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Clinical and Translational Medicine2024Vol. 14e1721

140

Dual-modal cellular nanoparticles for continuous neurotoxin detoxification

Kai, M.; Shen, W.; Yu, Y.; Wang, D.; Zhang, J.; Wang, S.; Fang, R.H.; Gao, W.; Zhang, L.

Nano Letters2024Vol. 247515-7523

139

Biohybrid microrobots locally and actively deliver drug-loaded nanoparticles to inhibit the progression of lung metastasis

Zhang, F.; Guo, Z.; Li, Z.; Luan, H.; Yu, Y.; Zhu, A.; Ding, S.; Gao, W.; Fang, R.H.; Zhang, L.; Wang, J.

Science Advances2024Vol. 10eadn6157

138

Platelet membrane-derived nanodiscs for neutralization of endogenous autoantibodies and exogenous virulence factors

Sun, L.; Yu, Y.; Peng, Y.; Wang, D.; Wang, S.; Noh, I.; Fang, R.H.; Gao, W.; Zhang, L.

Small2024Vol. 202308327

137

Protein-loaded cellular nanosponges for dual-biomimicry neurotoxin countermeasure

Wang, S.; Wang, D.; Shen, W.; Kai, M.; Yu, Y.; Peng, Y.; Xian, N.; Fang, R.H.; Gao, W.; Zhang, L.

Small2024Vol. 202309635

136

A modular approach to enhancing cell membrane-coated nanoparticle functionality using genetic engineering

Krishnan, N.; Jiang, Y.; Zhou, J.; Mohapatra, A.; Peng, F.; Duan, Y.; Holay, M.; Chekuri, S.; Guo, Z.; Gao, W.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Nature Nanotechnology2024Vol. 19345-353

135

Biohybrid microalgae robots: Design, fabrication, materials, and applications

Zhang, F.; Li, Z.; Chen, C.; Luan, H.; Fang, R.H.; Zhang, L.; Wang, J.

Advanced Materials2024Vol. 362303714

2023

134

Extending the in vivo residence time of macrophage membrane-coated nanoparticles through genetic modification

Duan, Y.; Zhou, J.; Zhou, Z.; Zhang, E.; Yu, Y.; Krishnan, N.; Silva-Ayala, D.; Fang, R.H.; Griffiths, A.; Gao, W.; Zhang, L.

Small2023Vol. 192305551

133

Biohybrid nanoparticles for treating arthritis

Fang, R.H.; Zhang, L.

Nature Nanotechnology2023Vol. 181387-1388

132

Glycan-modified cellular nanosponges for enhanced neutralization of botulinum toxin

Ai, X.; Wang, D.; Noh, I.; Duan, Y.; Zhou, Z.; Mukundan, N.; Fang, R.H.; Gao, W.; Zhang, L.

Biomaterials2023Vol. 302122330

131

Cancer cell membrane nanodiscs for antitumor vaccination

Guo, Z.; Noh, I.; Zhu, A.; Yu, Y.; Gao, W.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Nano Letters2023Vol. 237941-7949

130

Capsulated cellular nanosponges for the treatment of experimental inflammatory bowel disease

Duan, Y.; Zhang, E.; Fang, R.H.; Gao, W.; Zhang, L.

ACS Nano2023Vol. 1715893-15904

129

Immunostimulatory DNA hydrogel enhances protective efficacy of nanotoxoids against bacterial infection

Guo, Z.; Zhou, J.; Yu, Y.; Krishnan, N.; Noh, I.; Zhu, A.; Borum, R.; Gao, W.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Advanced Materials2023Vol. 352211717

128

Malaria biomimetic for tumor targeted drug delivery

Pihl, J.; Clausen, T.; Zhou, J.; Krishnan, N.; Ørum-Madsen, M.; Gustavsson, T.; Dagil, R.; Daugaard, M.; Choudhary, S.; Foged, C.; Esko, J.; Zhang, L.; Fang, R.H.*; Salanti, A.* (*Co-corresponding author)

ACS Nano2023Vol. 1713500-13509

127

Cell membrane-coated nanoparticles for the treatment of cancer

Krishnan, N.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Clinical and Translational Medicine2023Vol. 13e1285

126

A microstirring oral pill for improving the glucose-lowering effect of metformin

Mundaca-Uribe, R.; Holay, M.; Abbas, A.; Askarinam, N.; Sage-Sepulveda, J.; Kubiatowicz, L.; Fang, R.H.; Zhang, L.; Wang, J.

ACS Nano2023Vol. 179272-9279

125

Recent developments in nanoparticle-based photo-immunotherapy for cancer treatment

Guo, Z.; Zhu, A.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Small Methods2023Vol. 72300252

124

Synthesis of erythrocyte nanodiscs for bacterial toxin neutralization

Sun, L.; Wang, D.; Noh, I.; Fang, R.H.; Gao, W.; Zhang, L.

Angewandte Chemie International Edition2023Vol. 62e202301566

123

Genetically engineered cellular nanoparticles for biomedical applications

Krishnan, N.; Peng, F.; Mohapatra, A.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Biomaterials2023Vol. 296122065

122

Inhalable mRNA nanoparticles

Fang, R.H.; Zhang, L.

Nature Materials2023Vol. 22278-279

121

Outer membrane vesicle-coated nanoparticle vaccine protects against Acinetobacter baumannii pneumonia and sepsis

Bjanes, E.; Zhou, J.; Qayum, T.; Krishnan, N.; Zurich, R.; Menon, N.; Hoffman, A.; Fang, R.H.; Zhang, L.; Nizet, V.

Advanced NanoBiomed Research2023Vol. 32200130

120

Cellular nanodiscs made from bacterial outer membrane as a platform for antibacterial vaccination

Noh, I.; Guo, Z.; Zhou, J.; Gao, W.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

ACS Nano2023Vol. 171120-1127

119

Targeting drugs to tumours using cell membrane-coated nanoparticles

Fang, R.H.; Gao, W.; Zhang, L.

Nature Reviews Clinical Oncology2023Vol. 2033-48

2022

118

Extremophile-based biohybrid micromotors for biomedical operations in harsh acidic environments

Zhang, F.; Li, Z.; Duan, Y.; Luan, H.; Yin, L.; Guo, Z.; Chen, C.; Xu, M.; Gao, W.; Fang, R.H.; Zhang, L.; Wang, J.

Science Advances2022Vol. 8eade6455

117

mRNA nanomedicine: Design and recent applications

Kubiatowicz, L.; Mohapatra, A.; Krishnan, N.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Exploration2022Vol. 220210217

116

Single low-dose nanovaccine for long-term protection against anthrax toxins

Holay, M.; Krishnan, N.; Zhou, J.; Duan, Y.; Guo, Z.; Gao, W.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Nano Letters2022Vol. 229672-9678

115

Neuronal cellular nanosponges for effective detoxification of neurotoxins

Wang, D.; Ai, X.; Duan, Y.; Xian, N.; Fang, R.H.; Gao, W.; Zhang, L.

ACS Nano2022Vol. 1619145-19154

114

Nanoparticle-modified microrobots for in vivo antibiotic delivery to treat acute bacterial pneumonia

Zhang, F.; Zhuang, J.; Li, Z.; Gong, H.; Esteban-Fernández de Ávila, B.; Duan, Y.; Zhang, Q.; Zhou, J.; Yin, L.; Karshalev, E.; Gao, W.; Nizet, V.; Fang, R.H.; Zhang, L.; Wang, J.

Nature Materials2022Vol. 211324-1332

113

Gastrointestinal tract drug delivery using algae motors embedded in a degradable capsule

Zhang, F.; Li, Z.; Duan, Y.; Abbas, A.; Mundaca-Uribe, R.; Yin, L.; Luan, H.; Gao, W.; Fang, R.H.; Zhang, L.; Wang, J.

Science Robotics2022Vol. 7eabo4160

112

Using cell membranes as recognition layers to construct ultrasensitive and selective bioelectronic affinity sensors

Vargas, E.; Zhang, F.; Ben Hassine, A.; Ruiz-Valdepeñas Montiel, V.; Mundaca-Uribe, R.; Nandhakumar, P.; He, P.; Guo, Z.; Zhou, Z.; Fang, R.H.; Gao, W.; Zhang, L.; Wang, J.

Journal of the American Chemical Society2022Vol. 14417700-17708

111

Biomimetic neutrophil nanotoxoids elicit potent immunity against Acinetobacter baumannii in multiple models of infection

Zhou, J.; Ventura, C.; Yu, Y.; Gao, W.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Nano Letters2022Vol. 227057-7065

110

Nanotoxoid vaccination protects against opportunistic bacterial infections arising from immunodeficiency

Zhou, J.; Krishnan, N.; Guo, Z.; Ventura, C.; Holay, M.; Zhang, Q.; Wei, X.; Gao, W.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Science Advances2022Vol. 8eabq5492

109

Codelivery of antigens and adjuvant in polymeric nanoparticles coated with native parasite membranes induces protective mucosal immunity against Giardia lamblia

Zhou, J.; Miyamoto, Y.; Ihara, S.; Kroll, A.; Nieskens, N.; Tran, V.; Hanson, E.; Fang, R.H.; Zhang, L.; Eckmann, L.

The Journal of Infectious Diseases2022Vol. 226319-323

108

Membrane cholesterol depletion enhances enzymatic activity of cell-membrane-coated metal-organic-framework nanoparticles

Wang, S.; Kai, M.; Duan, Y.; Zhou, Z.; Fang, R.H.; Gao, W.; Zhang, L.

Angewandte Chemie International Edition2022Vol. 61e202203115

107

Bacterial membrane vesicles for vaccine applications

Krishnan, N.; Kubiatowicz, L.; Holay, M.; Zhou, J.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Advanced Drug Delivery Reviews2022Vol. 185114294

106

Organotropic targeting of biomimetic nanoparticles to treat lung disease

Holay, M.; Zhou, J.; Park, J.; Landa, I.; Ventura, C.; Gao, W.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Bioconjugate Chemistry2022Vol. 33586-593

105

Acute myeloid leukemia cell membrane-coated nanoparticles for cancer vaccination immunotherapy

Johnson, D.; Zhou, J.; Kroll, A.; Fang, R.H.; Yan, M.; Xiao, C.; Chen, X.; Kline, J.; Zhang, L.; Zhang, D.

Leukemia2022Vol. 36994-1005

104

Nanodelivery of STING agonists against cancer and infectious diseases

Zhou, J.; Ventura, C.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Molecular Aspects of Medicine2022Vol. 83101007

103

Virus-mimicking cell membrane-coated nanoparticles for cytosolic delivery of mRNA

Park, J.; Mohapatra, A.; Zhou, J.; Holay, M.; Krishnan, N.; Gao, W.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Angewandte Chemie International Edition2022Vol. 61e202113671

2021

102

Physical disruption of solid tumors by immunostimulatory microrobots enhances antitumor immunity

Zhou, J.; Karshalev, E.; Mundaca-Uribe, R.; Esteban-Fernández de Ávila, B.; Krishnan, N.; Xiao, C.; Ventura, C.; Gong, H.; Zhang, Q.; Gao, W.; Fang, R.H.; Wang, J.; Zhang, L.

Advanced Materials2021Vol. 332103505

101

Engineering of stimuli-responsive self-assembled biomimetic nanoparticles

Krishnan, N.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Advanced Drug Delivery Reviews2021Vol. 179114006

100

Surface glycan modification of cellular nanosponges to promote SARS-CoV-2 inhibition

Ai, X.; Wang, D.; Honko, A.; Duan, Y.; Gavrish, I.; Fang, R.H.; Griffiths, A.; Gao, W.; Zhang, L.

Journal of the American Chemical Society2021Vol. 14317615-17621

CD4+ T cell-mimicking nanoparticles encapsulating DIABLO/SMAC mimetics broadly neutralize HIV-1 and selectively kill HIV-1-infected cells

Campbell, G.; Zhuang, J.; Zhang, G.; Landa, I.; Kubiatowicz, L.; Dehaini, D.; Fang, R.H.; Zhang, L.; Spector, S.

Theranostics2021Vol. 119009-9021

Nanotoxoids: Biomimetic nanoparticle vaccines against infections

Guo, Z.; Kubiatowicz, L.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Advanced Therapeutics2021Vol. 42100072

Lure-and-kill macrophage nanoparticles alleviate the severity of experimental acute pancreatitis

Zhang, Q.; Zhou, J.; Zhou, J.; Fang, R.H.; Gao, W.; Zhang, L.

Nature Communications2021Vol. 124136

A microstirring pill enhances bioavailability of orally administered drugs

Mundaca-Uribe, R.; Karshalev, E.; Esteban-Fernández de Ávila, B.; Wei, X.; Nguyen, B.; Litvan, I.; Fang, R.H.; Zhang, L.; Wang, J.

Advanced Science2021Vol. 82100389

Genetically engineered cell membrane-coated nanoparticles for targeted delivery of dexamethasone to inflamed lungs

Park, J.; Jiang, Y.; Zhou, J.; Gong, H.; Mohapatra, A.; Heo, J.; Gao, W.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Science Advances2021Vol. 7eabf7820

Bacteria-inspired nanomedicine

Holay, M.; Guo, Z.; Pihl, J.; Heo, J.; Park, J.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

ACS Applied Bio Materials2021Vol. 43830-3848

Intratumoral immunotherapy using platelet-cloaked nanoparticles enhances antitumor immunity in solid tumors

Bahmani, B.; Gong, H.; Luk, B.; Haushalter, K.; DeTeresa, E.; Previti, M.; Zhou, J.; Gao, W.; Bui, J.; Zhang, L.; Fang, R.H.*; Zhang, J. (*Co-corresponding author)

Nature Communications2021Vol. 121999

Nanomaterial biointerfacing via mitochondrial membrane coating for targeted detoxification and molecular detection

Gong, H.; Zhang, Q.; Komarla, A.; Wang, S.; Duan, Y.; Zhou, Z.; Chen, F.; Fang, R.H.; Xu, S.; Gao, W.; Zhang, L.

Nano Letters2021Vol. 212603-2609

Nanotechnology for virus treatment

Zhou, J.; Krishnan, N.; Jiang, Y.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Nano Today2021Vol. 36101031

Cartilage-targeting ultrasmall lipid-polymer hybrid nanoparticles for the prevention of cartilage degradation

Ai, X.; Duan, Y.; Zhang, Q.; Sun, D.; Fang, R.H.; Liu-Bryan, R.; Gao, W.; Zhang, L.

Bioengineering & Translational Medicine2021Vol. 6e10187

2020

Zinc microrocket pills: Fabrication and characterization toward active oral delivery

Mundaca-Uribe, R.; Esteban-Fernández de Ávila, B.; Holay, M.; Lekshmy Venugopalan, P.; Nguyen, B.; Zhou, J.; Abbas, A.; Fang, R.H.; Zhang, L.; Wang, J.

Advanced Healthcare Materials2020Vol. 92000900

Natural display of nuclear-encoded RNA on the cell surface and its impact on cell interaction

Huang, N.; Fan, X.; Zaleta-Rivera, K.; Nguyen, T.; Zhou, J.; Luo, Y.; Gao, J.; Fang, R.H.; Yan, Z.; Chen, Z.; Zhang, L.; Zhong, S.

Genome Biology2020Vol. 21225

Nanoparticle–hydrogel superstructures for biomedical applications

Jiang, Y.; Krishnan, N.; Heo, J.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Journal of Controlled Release2020Vol. 324505-521

Engineered cell-membrane-coated nanoparticles directly present tumor antigens to promote anticancer immunity

Jiang, Y.; Krishnan, N.; Zhou, J.; Chekuri, S.; Wei, X.; Kroll, A.; Yu, C.; Duan, Y.; Gao, W.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Advanced Materials2020Vol. 322001808

Cellular nanosponges inhibit SARS-CoV-2 infectivity

Zhang, Q.; Honko, A.; Zhou, J.; Gong, H.; Downs, S.; Henao Vasquez, J.; Fang, R.H.; Gao, W.; Griffiths, A.; Zhang, L.

Nano Letters2020Vol. 205570-5574

Multicompartment tubular micromotors toward enhanced localized active delivery

Esteban-Fernández de Ávila, B.; Lopez-Ramirez, M.; Mundaca-Uribe, R.; Wei, X.; Ramírez-Herrera, D.; Karshalev, E.; Nguyen, B.; Fang, R.H.; Zhang, L.; Wang, J.

Advanced Materials2020Vol. 322000091

A biomimetic nanoparticle to “lure and kill” phospholipase A2

Zhang, Q.; Fang, R.H.; Gao, W.; Zhang, L.

Angewandte Chemie International Edition2020Vol. 5910461-10465

Enzyme-powered Janus platelet cell robots for active and targeted drug delivery

Tang, S.; Zhang, F.; Gong, H.; Wei, F.; Zhuang, J.; Karshalev, E.; Esteban-Fernández de Ávila, B.; Huang, C.; Zhou, Z.; Li, Z.; Yin, L.; Dong, H.; Fang, R.H.; Zhang, X.; Zhang, L.; Wang, J.

Science Robotics2020Vol. 5eaba6137

Multimodal enzyme delivery and therapy enabled by cell membrane-coated metal–organic framework nanoparticles

Zhuang, J.; Duan, Y.; Zhang, Q.; Gao, W.; Li, S.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Nano Letters2020Vol. 204051-4058

Biomimetic nanotechnology toward personalized vaccines

Zhou, J.; Kroll, A.; Holay, M.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Advanced Materials2020Vol. 321901255

Targeted gene silencing in vivo by platelet membrane-coated metal–organic framework nanoparticles

Zhuang, J.; Gong, H.; Zhou, J.; Zhang, Q.; Gao, W.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Science Advances2020Vol. 6eaaz6108

Biomimetic nanoparticle technology for cardiovascular disease detection and treatment

Park, J.; Dehaini, D.; Zhou, J.; Holay, M.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Nanoscale Horizons2020Vol. 525-42

2019

Group A streptococcal S protein utilizes red blood cells as immune camouflage and is a critical determinant for immune evasion

Wierzbicki, I.; Campeau, A.; Dehaini, D.; Holay, M.; Wei, X.; Greene, T.; Ying, M.; Sands, J.; Lamsa, A.; Zuniga, E.; Pogliano, K.; Fang, R.H.; LaRock, C.; Zhang, L.; Gonzalez, D.

Cell Reports2019Vol. 292979-2989.e15

Micromotors for active delivery of minerals toward the treatment of iron deficiency anemia

Karshalev, E.; Zhang, Y.; Esteban-Fernández de Ávila, B.; Beltrán-Gastélum, M.; Chen, Y.; Mundaca-Uribe, R.; Zhang, F.; Nguyen, B.; Tong, Y.; Fang, R.H.; Zhang, L.; Wang, J.

Nano Letters2019Vol. 197816-7826

Biomimetic nanosponges as a broad-spectrum countermeasure to biological threats

Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

HDIAC Journal2019Vol. 614-19

A nanomotor-based active delivery system for intracellular oxygen transport

Zhang, F.; Zhuang, J.; Esteban-Fernández de Ávila, B.; Tang, S.; Zhang, Q.; Fang, R.H.; Zhang, L.; Wang, J.

ACS Nano2019Vol. 1311996-12005

Nanoparticle delivery of immunostimulatory agents for cancer immunotherapy

Zhuang, J.; Holay, M.; Park, J.; Fang, R.H.; Zhang, J.; Zhang, L.

Theranostics2019Vol. 97826-7848

Engineering biological interactions on the nanoscale

Jiang, Y.; Chekuri, S.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Current Opinion in Biotechnology2019Vol. 581-8

Inhibition of pathogen adhesion by bacterial outer membrane-coated nanoparticles

Zhang, Y.; Chen, Y.; Lo, C.; Zhuang, J.; Angsantikul, P.; Zhang, Q.; Wei, X.; Zhou, Z.; Obonyo, M.; Fang, R.H.; Gao, W.; Zhang, L.

Angewandte Chemie International Edition2019Vol. 5811404-11408

Multiantigenic nanotoxoids for antivirulence vaccination against antibiotic-resistant gram-negative bacteria

Wei, X.; Ran, D.; Campeau, A.; Xiao, C.; Zhou, J.; Dehaini, D.; Jiang, Y.; Kroll, A.; Zhang, Q.; Gao, W.; Gonzalez, D.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Nano Letters2019Vol. 194760-4769

On the issue of transparency and reproducibility in nanomedicine

Leong, H.; Fang, R.H.; et al.

Nature Nanotechnology2019Vol. 14629-635

Cell-membrane-cloaked oil nanosponges enable dual-modal detoxification

Chen, Y.; Zhang, Y.; Zhuang, J.; Lee, J.; Wang, L.; Fang, R.H.; Gao, W.; Zhang, L.

ACS Nano2019Vol. 137209-7215

Selective cell death of latently HIV-infected CD4+ T cells mediated by autosis inducing nanopeptides

Zhang, G.; Luk, B.; Wei, X.; Campbell, G.; Fang, R.H.; Zhang, L.; Spector, S.

Cell Death & Disease2019Vol. 10419

Ligand-modified cell membrane enables the targeted delivery of drug nanocrystals to glioma

Chai, Z.; Ran, D.; Lu, L.; Zhan, C.; Ruan, H.; Hu, X.; Xie, C.; Jiang, K.; Li, J.; Zhou, J.; Wang, J.; Zhang, Y.; Fang, R.H.; Zhang, L.; Lu, W.

ACS Nano2019Vol. 135591-5601

Biomembrane-modified field effect transistors for sensitive and quantitative detection of biological toxins and pathogens

Gong, H.; Chen, F.; Huang, Z.; Gu, Y.; Zhang, Q.; Chen, Y.; Zhang, Y.; Zhuang, J.; Cho, Y.; Fang, R.H.; Gao, W.; Xu, S.; Zhang, L.

ACS Nano2019Vol. 133714-3722

Biomimetic micromotor enables active delivery of antigens for oral vaccination

Wei, X.; Beltran-Gastelum, M.; Karshalev, E.; Esteban-Fernandez de Avila, B.; Zhou, J.; Ran, D.; Angsantikul, P.; Fang, R.H.; Wang, J.; Zhang, L.

Nano Letters2019Vol. 191914-1921

Biomimetic nanosponges suppress in vivo lethality induced by the whole secreted proteins of pathogenic bacteria

Chen, Y.; Zhang, Y.; Chen, M.; Zhuang, J.; Fang, R.H.; Gao, W.; Zhang, L.

Small2019Vol. 151804994

Biomimetic nanoparticle vaccines for cancer therapy

Kroll, A.; Jiang, Y.; Zhou, J.; Holay, M.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Advanced Biosystems2019Vol. 31800219

2018

Biomimetic nanoemulsions for oxygen delivery in vivo

Zhuang, J.; Ying, M.; Spiekermann, K.; Holay, M.; Zhang, Y.; Chen, F.; Gong, H.; Lee, J.; Gao, W.; Fang, R.H.; Zhang, L.

Advanced Materials2018Vol. 301804693

Neutrophil membrane-coated nanoparticles inhibit synovial inflammation and alleviate joint damage in inflammatory arthritis

Zhang, Q.; Dehaini, D.; Zhang, Y.; Zhou, J.; Chen, X.; Zhang, L.; Fang, R.H.; Gao, W.; Zhang, L.

Nature Nanotechnology2018Vol. 131182-1190

T-cell-mimicking nanoparticles can neutralize HIV infectivity

Wei, X.; Zhang, G.; Ran, D.; Krishnan, N.; Fang, R.H.; Gao, W.; Spector, S.; Zhang, L.

Advanced Materials2018Vol. 301802233

Biomimetic targeting of nanoparticles to immune cell subsets via cognate antigen interactions

Luk, B.; Jiang, Y.; Copp, J.; Hu, C-M.; Krishnan, N.; Gao, W.; Li, S.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Molecular Pharmaceutics2018Vol. 153723-3728

Broad-spectrum neutralization of pore-forming toxins with human erythrocyte membrane-coated nanosponges

Chen, Y.; Chen, M.; Zhang, Y.; Lee, J.; Escajadillo, T.; Gong, H.; Fang, R.H.; Gao, W.; Nizet, V.; Zhang, L.

Advanced Healthcare Materials2018Vol. 71701366

Combatting infections with nanomedicine

Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Advanced Healthcare Materials2018Vol. 71800392

Coating nanoparticles with gastric epithelial cell membrane for targeted antibiotic delivery against Helicobacter pylori infection

Angsantikul, P.; Thamphiwatana, S.; Zhang, Q.; Spiekermann, K.; Zhuang, J.; Fang, R.H.; Gao, W.; Obonyo, M.; Zhang, L.

Advanced Therapeutics2018Vol. 11800016

Tissue repair and regeneration with endogenous stem cells

Xia, H.; Li, X.; Gao, W.; Fu, X.; Fang, R.H.; Zhang, L.; Zhang, K.

Nature Reviews Materials2018Vol. 3174-193

Cell membrane coating nanotechnology

Fang, R.H.; Kroll, A.; Gao, W.; Zhang, L.

Advanced Materials2018Vol. 301706759

Remote-loaded platelet vesicles for disease-targeted delivery of therapeutics

Ying, M.; Zhuang, J.; Wei, X.; Zhang, X.; Zhang, Y.; Jiang, Y.; Dehaini, D.; Chen, M.; Gu, S.; Gao, W.; Lu, W.; Fang, R.H.; Zhang, L.

Advanced Functional Materials2018Vol. 281801032

Defining host responses during systemic bacterial infection through construction of a murine organ proteome atlas

Lapek, J.; Mills, R.; Wozniak, J.; Campeau, A.; Fang, R.H.; Wei, X.; van de Groep, K.; Perez-Lopez, A.; van Sorge, N.; Raffatellu, M.; Knight, R.; Zhang, L.; Gonzalez, D.

Cell Systems2018Vol. 6579-592.e4

Biomimetic nanosponges for treating antibody-mediated autoimmune diseases

Jiang, Y.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Bioconjugate Chemistry2018Vol. 29870-877

Optical detection of abnormal skin scarring

Fang, R.H.; Zhang, L.

Nature Biomedical Engineering2018Vol. 2201-202

Toxoid vaccination against bacterial infection using cell membrane-coated nanoparticles

Angsantikul, P.; Fang, R.H.*; Zhang, L.* (*Co-corresponding author)

Bioconjugate Chemistry2018Vol. 29604-612

Nanoparticle functionalization with platelet membrane enables multifactored biological targeting and detection of atherosclerosis

Wei, X.; Ying, M.; Dehaini, D.; Su, Y.; Kroll, A.; Zhou, J.; Gao, W.; Fang, R.H.; Chien, S.; Zhang, L.

ACS Nano2018Vol. 12109-116

2017

Biomimetic virulomics for capture and identification of cell-type specific effector proteins

Lapek, J.; Fang, R.H.; Wei, X.; Li, P.; Wang, B.; Zhang, L.; Gonzalez, D.

ACS Nano2017Vol. 1111831-11838

Self-assembled colloidal gel using cell membrane-coated nanosponges as building blocks

Zhang, Y.; Gao, W.; Chen, Y.; Escajadillo, T.; Ungerleider, J.; Fang, R.H.; Christman, K.; Nizet, V.; Zhang, L.

ACS Nano2017Vol. 1111923-11930

Nanoparticulate delivery of cancer cell membrane elicits multiantigenic antitumor immunity

Kroll, A.*; Fang, R.H.*; Jiang, Y.; Zhou, J.; Wei, X.; Yu, C.; Gao, J.; Luk, B.; Dehaini, D.; Gao, W.; Zhang, L. (*Co-first author)

Advanced Materials2017Vol. 291703969

Remote loading of small-molecule therapeutics into cholesterol-enriched cell-membrane-derived vesicles

Zhang, X.; Angsantikul, P.; Ying, M.; Zhuang, J.; Zhang, Q.; Wei, X.; Jiang, Y.; Zhang, Y.; Dehaini, D.; Chen, M.; Chen, Y.; Gao, W.; Fang, R.H.; Zhang, L.

Angewandte Chemie International Edition2017Vol. 5614075-14079

A facile approach to functionalizing cell membrane-coated nanoparticles with neurotoxin-derived peptide for brain-targeted drug delivery

Chai, Z.; Hu, X.; Wei, X.; Zhan, C.; Lu, L.; Jiang, K.; Su, B.; Ruan, H.; Ran, D.; Fang, R.H.; Zhang, L.; Lu, W.

Journal of Controlled Release2017Vol. 264102-111

Macrophage-like nanoparticles concurrently absorbing endotoxins and proinflammatory cytokines for sepsis management

Thamphiwatana, S.; Angsantikul, P.; Escajadillo, T.; Zhang, Q.; Olson, J.; Luk, B.; Zhang, S.; Fang, R.H.; Gao, W.; Nizet, V.; Zhang, L.

Proceedings of the National Academy of Sciences2017Vol. 11411488-11493

Erythrocyte membrane-coated nanogel for combinatorial antivirulence and responsive antimicrobial delivery against Staphylococcus aureus infection

Zhang, Y.; Zhang, J.; Chen, W.; Angsantikul, P.; Spiekermann, K.; Fang, R.H.; Gao, W.; Zhang, L.

Journal of Controlled Release2017Vol. 263185-191

Preparation of particulate polymeric therapeutics for medical applications

Zhuang, J.; Fang, R.H.; Zhang, L.

Small Methods2017Vol. 11700147

In situ capture of bacterial toxins for antivirulence vaccination

Wei, X.; Gao, J.; Wang, F.; Ying, M.; Angsantikul, P.; Kroll, A.; Zhou, J.; Gao, W.; Lu, W.; Fang, R.H.; Zhang, L.

Advanced Materials2017Vol. 291701644

Cell membrane-derived nanomaterials for biomedical applications

Fang, R.H.; Jiang, Y.; Fang, J.; Zhang, L.

Biomaterials2017Vol. 12869-83

Erythrocyte-platelet hybrid membrane coating for enhanced nanoparticle functionalization

Dehaini, D.; Wei, X.; Fang, R.H.; Masson, S.; Angsantikul, P.; Luk, B.; Zhang, Y.; Ying, M.; Jiang, Y.; Kroll, A.; Gao, W.; Zhang, L.

Advanced Materials2017Vol. 291606209

Biointerfacing and applications of cell membrane-coated nanoparticles

Kroll, A.; Fang, R.H.; Zhang, L.

Bioconjugate Chemistry2017Vol. 2823-32

2016

Nanoparticles camouflaged in platelet membrane coating as an antibody decoy for the treatment of immune thrombocytopenia

Wei, X.; Gao, J.; Fang, R.H.; Luk, B.; Kroll, A.; Dehaini, D.; Zhou, J.; Kim, H.; Gao, W.; Lu, W.; Zhang, L.

Biomaterials2016Vol. 111116-123

Ultra-small lipid-polymer hybrid nanoparticles for tumor-penetrating drug delivery

Dehaini, D.; Fang, R.H.; Luk, B.; Pang, Z.; Hu, C-M.; Kroll, A.; Yu, C.; Gao, W.; Zhang, L.

Nanoscale2016Vol. 814411-14419

Nanoparticle-based modulation of the immune system

Fang, R.H.; Zhang, L.

Annual Review of Chemical and Biomolecular Engineering2016Vol. 7305-326

Coating nanofiber scaffolds with beta cell membrane to promote cell proliferation and function

Chen, W.; Zhang, Q.; Luk, B.; Fang, R.H.; Liu, Y.; Gao, W.; Zhang, L.

Nanoscale2016Vol. 810364-10370

Safe and immunocompatible nanocarriers cloaked in RBC membranes for drug delivery to treat solid tumors

Luk, B.; Fang, R.H.; Hu, C-M.; Copp, J.; Thamphiwatana, S.; Dehaini, D.; Gao, W.; Zhang, K.; Li, S.; Zhang, L.

Theranostics2016Vol. 61004-1011

Nanoparticle-based antivirulence vaccine for the management of methicillin-resistant Staphylococcus aureus skin infection

Wang, F.; Fang, R.H.; Luk, B.; Hu, C-M.; Thamphiwatana, S.; Dehaini, D.; Angsantikul, P.; Kroll, A.; Pang, Z.; Gao, W.; Lu, W.; Zhang, L.

Advanced Functional Materials2016Vol. 261628-1635

Biomimetic strategies for targeted nanoparticle delivery

Dehaini, D.; Fang, R.H.; Zhang, L.

Bioengineering & Translational Medicine2016Vol. 130-46

2015

Nanoparticle-based manipulation of antigen-presenting cells for cancer immunotherapy

Fang, R.H.; Kroll, A.; Zhang, L.

Small2015Vol. 115483-5496

Nanoparticle biointerfacing by platelet membrane cloaking

Hu, C-M.*; Fang, R.H.*; Wang, K.*; Luk, B.; Thamphiwatana, S.; Dehaini, D.; Nguyen, P.; Angsantikul, P.; Wen, C.; Kroll, A.; Carpenter, C.; Ramesh, M.; Qu, V.; Patel, S.; Zhu, J.; Shi, W.; Hofman, F.; Chen, T.; Gao, W.; Zhang, K.; Chien, S.; Zhang, L. (*Co-first author)

Nature2015Vol. 526118-121