Fang Lab publication

Microrobots for pulmonary drug delivery

Li, Z.; Luan, H.; Fang, Z.; Ding, S.; Kobrin, R.; Fang, R.H.; Zhang, L.; Wang, J.

Nature Reviews Bioengineering 2026Vol. 4319-335

Summary

This review examines the challenges of pulmonary drug delivery, such as mucociliary clearance and immune barriers, and explores how microrobots can overcome these obstacles through active propulsion, targeted navigation, and controlled release. It highlights key design considerations and applications of biohybrid platforms, including algae-based and inhalable microrobots for treating pneumonia and lung metastasis. The significance lies in connecting lung physiology with microrobot engineering to enable more effective and localized therapy.