Dispersion-based methods for the engineering and manufacture of polymeric nanoparticles for drug delivery applications

Summary

This review examines dispersion-based methods for fabricating polymeric nanoparticles for drug delivery, focusing on lab-scale techniques (emulsification-diffusion, salting-out, nanoprecipitation) and their scale-up potential. The principal finding is that nanoprecipitation is the most promising for large-scale production due to its simplicity and reproducibility, and that fluidic devices like the multi-inlet vortex reactor enable continuous synthesis with tunable properties. The significance lies in the potential of these scalable methods to facilitate clinical translation of polymeric nanoparticle drug delivery systems.